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Vitamin B12 Prevents Cimetidine-Induced Androgenic Failure and Damage to Sperm Quality in Rats

Cimetidine, used as an anti-ulcer and adjuvant treatment in cancer therapy, causes disorders in the male reproductive tract, including steroidogenesis. However, its effect on sperm quality and male fertility has been poorly addressed. Since vitamin B12 has demonstrated to recover spermatogonia numbe...

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Main Authors: Flávia Luciana Beltrame, Fabiane de Santi, Vanessa Vendramini, Regina Elizabeth Lourenço Cabral, Sandra Maria Miraglia, Paulo Sérgio Cerri, Estela Sasso-Cerri
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Endocrinology
Subjects:
cimetidine
vitamin B12
sperm quality
spermiogenesis
androgenic dysfunction
DNA damage
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2019.00309/full
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