In silico clinical trial evaluating lisdexamfetamine’s and methylphenidate’s mechanism of action computational models in an attention-deficit/hyperactivity disorder virtual patients’ population

IntroductionAttention-deficit/hyperactivity disorder (ADHD) is an impairing psychiatric condition with the stimulants, lisdexamfetamine (LDX), and methylphenidate (MPH), as the first lines pharmacological treatment.MethodsHerein, we applied a novel in silico method to evaluate virtual LDX (vLDX) and...

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Главные авторы:	José Ramón Gutiérrez-Casares, Javier Quintero, Cristina Segú-Vergés, Pilar Rodríguez Monterde, Tamara Pozo-Rubio, Mireia Coma, Carmen Montoto
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Frontiers Media S.A. 2023-06-01
Серии:	Frontiers in Psychiatry
Предметы:	attention-deficit/hyperactivity disorder lisdexamfetamine methylphenidate mathematical modeling in silico clinical trial
Online-ссылка:	https://www.frontiersin.org/articles/10.3389/fpsyt.2023.939650/full
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