Immunogenicity of DNA vaccines encoding simian immunodeficiency virus antigen targeted to dendritic cells in rhesus macaques.

BACKGROUND: Targeting antigens encoded by DNA vaccines to dendritic cells (DCs) in the presence of adjuvants enhances their immunogenicity and efficacy in mice. METHODOLOGY/PRINCIPAL FINDINGS: To explore the immunogenicity of this approach in non-human primates, we generated a single chain antibody...

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Autors principals:	Matthias Tenbusch, Ralf Ignatius, Godwin Nchinda, Christine Trumpfheller, Andres M Salazar, Katharina Töpfer, Ulrike Sauermann, Ralf Wagner, Drew Hannaman, Klara Tenner-Racz, Paul Racz, Christiane Stahl-Hennig, Klaus Uberla
Format:	Artigo
Idioma:	Inglês
Publicat:	Public Library of Science (PLoS) 2012-01-01
Col·lecció:	PLoS ONE
Accés en línia:	http://europepmc.org/articles/PMC3373620?pdf=render
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