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The BACHD Rat Model of Huntington Disease Shows Specific Deficits in a Test Battery of Motor Function

Rationale: Huntington disease (HD) is a progressive neurodegenerative disorder characterized by motor, cognitive and neuropsychiatric symptoms. HD is usually diagnosed by the appearance of motor deficits, resulting in skilled hand use disruption, gait abnormality, muscle wasting and choreatic moveme...

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Principais autores: Giuseppe Manfré, Erik K. H. Clemensson, Elisavet I. Kyriakou, Laura E. Clemensson, Johanneke E. van der Harst, Judith R. Homberg, Huu Phuc Nguyen
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017-11-01
coleção:Frontiers in Behavioral Neuroscience
Assuntos:
Huntington disease
polyglutamine disease
model characterization
motor function
transgenic rat
neurodegenerative disorders
Acesso em linha:http://journal.frontiersin.org/article/10.3389/fnbeh.2017.00218/full
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