Pharmacological inhibition of host pathways enhances macrophage killing of intracellular bacterial pathogens

ABSTRACT After ingestion into macrophage phagosomes, some bacterial pathogens such as Mycobacterium tuberculosis (Mtb) evade killing by preventing phagosome acidification and fusion of the phagosome with a lysosome. Mtb accumulates extracellular polyphosphate (polyP), and polyP inhibits macrophage p...

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Autori principali:	Ramesh Rijal, Richard H. Gomer
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology 2026-01-01
Serie:	Microbiology Spectrum
Soggetti:	polyphosphate signaling macrophage signaling pathways intracellular pathogens host-pathogen interactions host-directed therapies
Accesso online:	https://journals.asm.org/doi/10.1128/spectrum.02163-25
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