Novel m5C-dependent post-transcriptional regulation of KIF11 drives lymphatic metastasis in gastric cancer

Abstract Lymphatic metastasis is a critical determinant of poor prognosis in gastric cancer (GC), yet the underlying regulatory mechanisms remain incompletely understood. While kinesin family member 11 (KIF11) is known to promote lymphangiogenesis, its upstream post-transcriptional regulation in GC...

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Autori principali:	Yi Zhang, Ruofan He, Jianxin Ye, Xiaoxin Xu, Xinyi Gui, Yi Wu, Xinjian Lin, Xu Lin, Kunqi Chen
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Portfolio 2025-12-01
Serie:	Scientific Reports
Soggetti:	Gastric cancer Lymphatic metastasis 5-methylcytosine RNA modification (m5C) KIF11
Accesso online:	https://doi.org/10.1038/s41598-025-28773-1
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