Elucidating a novel prognostic signature for bladder cancer by integrating hypoxia and lactate metabolism-related genes: comprehensive bioinformatics analyses and experimental evidence

Abstract Background Bladder cancer (BLCA) is a highly heterogeneous malignancy with high morbidity and mortality. Massive lactate production and hypoxia are characteristics of the tumor microenvironment (TME). However, our understanding of the clinical value of hypoxia and lactate metabolism (HLM) i...

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Detalhes bibliográficos

Principais autores:	Yihao Zhao, Peixin Li, Zhe Shen, Shengwen Yao, Xiaoyi Zhang, Nianzhao Zhang, Jun Chen
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-11-01
Colecção:	BMC Cancer
Assuntos:	Bladder cancer Hypoxia Lactate metabolism Tumor microenvironment Prognosis
Acesso em linha:	https://doi.org/10.1186/s12885-025-15010-1
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