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The gut microbiome influences the bioavailability of olanzapine in rats

Background: The role of the gut microbiome in the biotransformation of drugs has recently come under scrutiny. It remains unclear whether the gut microbiome directly influences the extent of drug absorbed after oral administration and thus potentially alters clinical pharmacokinetics. Methods: In th...

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Principais autores: Sofia Cussotto, Jacinta Walsh, Anna V. Golubeva, Alexander V. Zhdanov, Conall R. Strain, Fiona Fouhy, Catherine Stanton, Timothy G. Dinan, Niall P. Hyland, Gerard Clarke, John F. Cryan, Brendan T. Griffin
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2021-04-01
Serier:EBioMedicine
Fag:
Antipsychotic
Microbiome
Pharmacokinetics
Diversity
Bioavailability
CYP
Online adgang:http://www.sciencedirect.com/science/article/pii/S2352396421001006
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