C-Terminal p53 Palindromic Tetrapeptide Restores Full Apoptotic Function to Mutant p53 Cancer Cells In Vitro and In Vivo

We previously demonstrated that a synthetic monomer peptide derived from the C-terminus of p53 (aa 361–382) induced preferential apoptosis in mutant p53 malignant cells, but not normal cells. The major problem with the peptide was its short half-life (half-life < 10 min.) due to a random coil topolo...

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Egile Nagusiak:	Robert L. Fine, Yuehua Mao, Richard Dinnen, Ramon V. Rosal, Anthony Raffo, Uri Hochfeld, Patrick Senatus, Jeffrey N. Bruce, Gwen Nichols, Hsin Wang, Yongliang Li, Paul W. Brandt-Rauf
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	MDPI AG 2023-01-01
Saila:	Biomedicines
Gaiak:	p53 p53 peptide apoptosis breast cancer Fas Bax
Sarrera elektronikoa:	https://www.mdpi.com/2227-9059/11/1/137
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