Prefusion-stabilized Hantaan virus glycoprotein nucleic acid vaccine elicits potent neutralizing antibody responses via germinal center activation

Abstract Old World orthohantaviruses, including Hantaan virus (HTNV), cause hemorrhagic fever with renal syndrome (HFRS) in Eurasia. Available inactivated vaccines often induce low neutralizing antibodies and short-term protection. We evaluated nucleic acid vaccines expressing a prefusion-stabilized...

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Detalhes bibliográficos

Principais autores:	Wei Ye, Yamei Dang, Yuan Wang, Qiqi Yang, Hui Zhang, Chuantao Ye, Jing Wei, Jiawei Pei, Xuemin Pei, Dongshen Jiang, Xiaojing Yang, Xiaolei Jin, Hongwei Ma, He Liu, Liang Zhang, Linfeng Cheng, Yangchao Dong, Yingfeng Lei, Zhikai Xu, Fanglin Zhang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2026-03-01
Colecção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-026-70285-7
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