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Haploinsufficiency of Trp53 dramatically extends the lifespan of Sirt6-deficient mice

Mammalian sirtuin 6 (Sirt6) is a conserved NAD+-dependent deacylase and mono-ADP ribosylase that is known to be involved in DNA damage repair, metabolic homeostasis, inflammation, tumorigenesis, and aging. Loss of Sirt6 in mice results in accelerated aging and premature death within a month. Here, w...

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Principais autores: Shrestha Ghosh, Sheung Kin Wong, Zhixin Jiang, Baohua Liu, Yi Wang, Quan Hao, Vera Gorbunova, Xinguang Liu, Zhongjun Zhou
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications Ltd 2018-02-01
coleção:eLife
Assuntos:
SIRT6
Trp53
lifespan extention
acetylation
premature aging
mice
Acesso em linha:https://elifesciences.org/articles/32127
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