Therapy of CF-Patients with Amitriptyline and Placebo - a Randomised, Double-Blind, Placebo-Controlled Phase IIb Multicenter, Cohort-Study

Background/Aims: Several recent studies revealed an accumulation of ceramide in bronchial, tracheal and intestinal epithelial cells of mice and patients with cystic fibrosis (CF). Normalization of ceramide concentrations in lungs of CF mice employing the functional acid sphingomyelinase inhibitor am...

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Ngā kaituhi matua:	Lutz Nährlich, Jochen G. Mainz, Constantin Adams, Corinna Engel, Gloria Herrmann, Vanya Icheva, Josefine Lauer, Caroline Deppisch, Andreas Wirth, Katy Unger, Ute Graepler-Mainka, Andreas Hector, Susanne Heyder, Martin Stern, Gerd Döring, Erich Gulbins, Joachim Riethmüller
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Cell Physiol Biochem Press GmbH & Co KG 2013-04-01
Rangatū:	Cellular Physiology and Biochemistry
Ngā marau:	Cystic Fibrosis Amitriptyline P. aeruginosa Ceramide CFTR
Urunga tuihono:	http://www.karger.com/Article/FullText/350071
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!