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Immune sentinel function of nasal mucosal epithelial cells in allergic rhinitis: a review on barrier damage and inflammatory amplification loops regulated by calcium signalling

Allergic rhinitis (AR) is a prevalent chronic inflammatory disorder characterized by complex pathophysiological mechanisms. Nasal mucosal epithelial cells serve as crucial “immune sentinels” that detect allergens and initiate immune responses, thereby playing a pivotal role in disease progression. I...

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Principais autores: Yiting Liu, Qingjia Sun, Cuida Meng, Jichao Sha, Dongdong Zhu, Nan Wu
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2026-03-01
Serier:Frontiers in Immunology
Fag:
allergic rhinitis
barrier damage
calcium signaling
immune sentinel
inflammatory amplification loop
nasal mucosal epithelial cells
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2026.1761813/full
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