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Determination of resilience of a panel of broadly neutralizing mAbs to emerging variants of SARS-CoV-2 generated using reverse genetics

Summary: SARS-CoV-2 continues to evolve, and its emerging variants might escape the immune responses generated by existing vaccines and therapeutic mAbs. Accordingly, rapid analysis of their possible neutralization phenotype is essential and can be facilitated by reverse genetics (RGs) systems to re...

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Principais autores: Madeeha Afzal, Diana Melnyk, Thomas Courty, Lisa Schimanski, Michelle Hill, Stuart Neil, Tiong Kit Tan, William S. James
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2025-06-01
Series:iScience
Assuntos:
Biological sciences
Genetics
Immunology
Immune system evolution
Immunity
Acceso en liña:http://www.sciencedirect.com/science/article/pii/S2589004225007126
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