Comparative assessment of tissue cross-reactivity and pharmacokinetic half-life of malaria monoclonal antibodies

IntroductionMonoclonal antibodies (mAbs) targeting the Plasmodium falciparum circumsporozoite protein (CSP) are leading clinical candidates for malaria prevention in travelers, military personnel, and pregnant women. Off-target binding and pharmacokinetics (PK) are important considerations during hi...

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Autores principales:	William R. Fugina, Dallas R. Brown, Shelby Foor, Emma C. Ryan, Samuel Cuevas, Shreeram Nallar, Dawn Wolf, Renita Brown, Jesse P. Deluca, Geoffrey C. Chin, Elizabeth J. Raymond, James T. Raymond, Phil S. Medlin, Sheetij Dutta
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Frontiers Media S.A. 2026-06-01
Colección:	Frontiers in Immunology
Materias:	circumsporozoite protein mAb 311 mAb 317 malaria monoclonal antibody (mAb) rhesus macaque
Acceso en línea:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1848315/full
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