Structural and Dynamics Perspectives on the Binding of Substrate and Inhibitors in Mycobacterium tuberculosis DHFR

Dihydrofolate reductase (DHFR), an essential enzyme in the folate pathway, is a potential target for new anti-tuberculosis drugs. Fifteen crystal structures of Mycobacterium tuberculosis DHFR complexed with NADPH and various inhibitors are available in the RCSB Protein Data Bank, but none of them is...

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Hlavní autoři:	Pimonluck Sittikornpaiboon, Pisanu Toochinda, Luckhana Lawtrakul
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2017-09-01
Edice:	Scientia Pharmaceutica
Témata:	molecular dynamics simulations antifolates protein-ligand interactions
On-line přístup:	https://www.mdpi.com/2218-0532/85/3/31
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