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In Silico and in vitro antiviral activity of FDA approved drugs from ZINC database against RNA-dependent RNA polymerase of dengue virus

Abstract Dengue is a frequent mosquito borne infection with no antiviral medications approved and drug repurposing is an economical and time-saving method of creating an efficient therapy. This research has chosen RNA-dependent RNA polymerase (RdRp) of non-structural protein 5 (NS5) of dengue virus...

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Autori principali: Alia Uzma, Adiba, Ammara Kausar, Muhammad Waseem Aslam, Liaqat Ali, Mahwish Ali, Asma Saleem Qazi, Abdul Haq, Deeba Amraiz, Emad Rashad Sindi, Taha Alqahtani, Magdi E. A. Zaki, Molalign Assefa
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2026-03-01
Serie:Virology Journal
Soggetti:
Dengue virus
 In silico
RNA-dependent RNA polymerase
Vero cells
Cytotoxicity
Doxorubicin
Accesso online:https://doi.org/10.1186/s12985-026-03110-8
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