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TREM2 promotes adipogenesis of PDGFR-α+ adipose stem cells but is dispensable for adipose remodeling and metabolic health during diet-induced obesity

White adipose tissue (WAT) expands through adipocyte hypertrophy or hyperplasia-associated differentiation of progenitor adipose stem cells (ASC). The triggering receptor expressed on myeloid cells 2 (TREM2) reportedly promotes adipocyte differentiation and whole body TREM2 deletion in mice leads to...

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Autori principali: Anja Dobrijevic, Ana Korosec, Julia Stefanie Brunner, Lenka Matejovicova, Anna Gemza, Karin Lakovits, Hon Shing Lam, Aloña Agirre-Lizaso, Gernot Schabbauer, Sylvia Knapp, Omar Sharif
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2026-04-01
Serie:Frontiers in Endocrinology
Soggetti:
adipogenesis
adipose stem cell
metabolic health
obesity
TREM2
white adipose tissue
Accesso online:https://www.frontiersin.org/articles/10.3389/fendo.2026.1738472/full
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