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Design, synthesis, in-silico studies and apoptotic activity of novel amide enriched 2-(1H)- quinazolinone derivatives

Cancer is a broad classification of diseases that can affect any organ or body tissue due to aberrant cellular proliferation for unknown reasons. Many present chemotherapeutic drugs are highly toxic and have little selectivity. Additionally, they lead to the development of medication resistance. The...

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Principais autores: Naganjaneyulu Gariganti, Anjaneyulu Bandi, K.R.S. Naresh Gatta, Jishu Pagag, Lalitha Guruprasad, Bhaskar Poola, Ravi K. Kottalanka
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2024-05-01
coleção:Heliyon
Assuntos:
Quinazolinone
Apoptotic activity
SARS studies
Molecular docking
MD simulations
ADME analysis
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2405844024063230
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