Targeting ENO1 reprograms macrophage polarization to trigger antitumor immunity and improves the therapeutic effect of radiotherapy

Abstract Enolase 1 (ENO1) is a glycolytic enzyme involved in tumor progression that performs a variety of classical and nonclassical functions. However, the mechanism by which it promotes tumor progression is still not fully understood. Here, we revealed that TGFβ1/Smad3 signaling triggered the symm...

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Autores principales:	Yu-Sen Lin, Hsin-Yu Chang, Wei-Ze Hong, Jhen-Yu Chen, Wei-Ching Huang, Ta-Tung Yuan, Tao-Wei Ke, Yuan-Yao Tsai, Te-Hong Chen, Ji-An Liang, Jui-I Chao, K. S. Clifford Chao, Kevin Chih-Yang Huang
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Nature Publishing Group 2026-02-01
Colección:	Cell Death and Disease
Acceso en línea:	https://doi.org/10.1038/s41419-026-08416-7
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