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ZNF506-dependent positive feedback loop regulates H2AX signaling after DNA damage

Following double-strand break a cascade of events leads to the recruitment of repair factors to damaged sites. Here the authors identify ZNF506 as a key factor that mediates post-translational modification changes in H2AX affecting the DNA damage response.

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Bibliografische gegevens
Hoofdauteurs: Somaira Nowsheen, Khaled Aziz, Kuntian Luo, Min Deng, Bo Qin, Jian Yuan, Karthik B. Jeganathan, Jia Yu, Henan Zhang, Wei Ding, Jan M. van Deursen, Zhenkun Lou
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Portfolio 2018-07-01
Reeks:Nature Communications
Online toegang:https://doi.org/10.1038/s41467-018-05161-0
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