An intrinsically disordered region mediates RNA-binding selectivity and cellular activities of LARP6

Abstract Intrinsically disordered regions (IDRs) are prevalent in RNA-binding proteins (RBPs), yet their roles in RNA interactions remain poorly defined. We examined RNA-binding regulation by structured and disordered regions of LARP6, an RBP with a diverse RNA-binding repertoire. Mass spectrometry-...

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Principais autores:	Federica Capraro, Giancarlo Abis, Alessio Incocciati, Peter J. Simpson, Mehran Karimzadeh, Laura Masino, Alexander Barley, Tam T. T. Bui, Geoff Kelly, Hani Goodarzi, Maria R. Conte, Faraz K. Mardakheh
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Nature Portfolio 2026-02-01
סדרה:	Nature Communications
גישה מקוונת:	https://doi.org/10.1038/s41467-026-69789-z
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