Adaption of the plasmin generation assay to enhance sensitivity to plasminogen activator inhibitor-1 and establishment of sex-specific reference values in human plasma

Background: Pharmacologic modifiers of fibrinolysis are used to modulate bleeding and thrombosis. Characterization of a sensitive plasmin generation (PG) assay to identify abnormal fibrinolytic states and monitor antifibrinolytic medication may improve clinical care. Objectives: To establish referen...

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Autori principali:	Ilaria De Simone, Kieran Pocknell, Samia Tufaha, Joke Konings, Mark Roest, Alisa S. Wolberg, Claire S. Whyte, Nicola J. Mutch, Bas de Laat, Dana Huskens
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2026-03-01
Serie:	Research and Practice in Thrombosis and Haemostasis
Soggetti:	fibrinolysis plasminogen plasmin plasminogen activators antifibrinolytic agents
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2475037926000932
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