Effects of APOE ε2 on the Fractional Amplitude of Low-Frequency Fluctuation in Mild Cognitive Impairment: A Study Based on the Resting-State Functional MRI

BackgroundApolipoprotein E (APOE) ε2 is a protective genetic factor for Alzheimer’s disease (AD). However, the potential interaction effects between the APOE ε2 allele and disease status on the intrinsic brain activity remain elusive.MethodsWe identified 73 healthy control (HC) with APOE ε3/ε3, 61 m...

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Detalhes bibliográficos

Principais autores:	Xiaocao Liu, Qingze Zeng, Xiao Luo, Kaicheng Li, Hui Hong, Shuyue Wang, Xiaojun Guan, Jingjing Wu, Ruiting Zhang, Tianyi Zhang, Zheyu Li, Yanv Fu, Tao Wang, Chao Wang, Xiaojun Xu, Peiyu Huang, Minming Zhang, for the Alzheimer’s Disease Neuroimaging Initiative (ADNI)
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2021-04-01
coleção:	Frontiers in Aging Neuroscience
Assuntos:	resting-state functional MRI APOE Alzheimer’s disease mild cognitive impairment fractional amplitude of low-frequency fluctuation
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fnagi.2021.591347/full
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