Structure-based screening and a conformational biosensor identify a GPR183 inverse agonist and an activation switch

Abstract GPR183 is a chemotactic GPCR involved in immune cell migration. Using AI-driven virtual screening and biophysical assays, we identify inverse agonists. From 70 compounds and a subsequent hit expansion, compound 78 emerges as a potent inhibitor of constitutive and agonist-induced Gi signalin...

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Bibliografske podrobnosti

Principais autores:	Louise Andersson, Michele Roggia, Kittikorn Wangriatisak, Rhiannon Skye Kozel, Holly R. Brittain, Sonia Youhanna, Maria Gil, Mathias Haag, Volker M. Lauschke, Karine Chemin, Sandro Cosconati, Paweł Kozielewicz
Format:	Artigo
Jezik:	Inglês
Izdano:	Nature Portfolio 2026-05-01
Serija:	Nature Communications
Online dostop:	https://doi.org/10.1038/s41467-026-73857-9
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