Unique Cellular and Biochemical Features of Human Mitochondrial Peroxiredoxin 3 Establish the Molecular Basis for Its Specific Reaction with Thiostrepton

A central hallmark of tumorigenesis is metabolic alterations that increase mitochondrial reactive oxygen species (mROS). In response, cancer cells upregulate their antioxidant capacity and redox-responsive signaling pathways. A promising chemotherapeutic approach is to increase ROS to levels incompa...

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Hlavní autoři:	Kimberly J. Nelson, Terri Messier, Stephanie Milczarek, Alexis Saaman, Stacie Beuschel, Uma Gandhi, Nicholas Heintz, Terrence L. Smalley, W. Todd Lowther, Brian Cunniff
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2021-01-01
Edice:	Antioxidants
Témata:	mitochondrial reactive oxygen species peroxiredoxin 3 pro-oxidant therapy thiostrepton
On-line přístup:	https://www.mdpi.com/2076-3921/10/2/150
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