TGFβ1-induced SMAD2/3 and SMAD1/5 phosphorylation are both ALK5-kinase-dependent in primary chondrocytes and mediated by TAK1 kinase activity

Abstract Background Dysregulated transforming growth factor β (TGFβ) signaling is implicated in osteoarthritis development, making normalizing TGFβ signaling a possible therapy. Theoretically, this can be achieved with small molecule inhibitors specifically targeting the various TGFβ receptors and d...

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Detalhes bibliográficos

Principais autores:	Arjan van Caam, Wojciech Madej, Amaya Garcia de Vinuesa, Marie-José Goumans, Peter ten Dijke, Esmeralda Blaney Davidson, Peter van der Kraan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2017-05-01
coleção:	Arthritis Research & Therapy
Assuntos:	TGFβ Smad Small molecule inhibitor ALK1 ALK5 TAK1
Acesso em linha:	http://link.springer.com/article/10.1186/s13075-017-1302-4
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