Research progress of DNA damage repair (DDR) and DDR inhibitors in tumor immunotherapy

Abstract Human cells possess a complex network of regulatory systems——the DNA damage repair pathway (DDR), to deal with various DNA damage to prevent the inheritance of deleterious mutations. DDR perform its functions via cell cycle checkpoint activation. Mutations in the DDR gene are also the basis...

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Principais autores:	Qi Liu, Chunmei Zhang, Yixuan Gao, Dongmei Feng, Duo Deng, Yun Pan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-12-01
coleção:	World Journal of Surgical Oncology
Assuntos:	DDR Tumor immunotherapy Molecule inhibitors Immune checkpoint inhibitors POLE/POLD PARP inhibitors
Acesso em linha:	https://doi.org/10.1186/s12957-025-04101-9
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