Construction and Immunogenicity Evaluation of Recombinant Influenza A Viruses Containing Chimeric Hemagglutinin Genes Derived from Genetically Divergent Influenza A H1N1 Subtype Viruses.

<h4>Background and objectives</h4>Influenza A viruses cause highly contagious diseases in a variety of hosts, including humans and pigs. To develop a vaccine that can be broadly effective against genetically divergent strains of the virus, in this study we employed molecular breeding (DNA shuffling)...

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Detalhes bibliográficos

Principais autores:	Kara McCormick, Zhiyong Jiang, Longchao Zhu, Steven R Lawson, Robert Langenhorst, Russell Ransburgh, Colin Brunick, Miranda C Tracy, Heather R Hurtig, Leah M Mabee, Mark Mingo, Yanhua Li, Richard J Webby, Victor C Huber, Ying Fang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Public Library of Science (PLoS) 2015-01-01
coleção:	PLoS ONE
Acesso em linha:	https://doi.org/10.1371/journal.pone.0127649
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