Structure and phospholipase function of peroxiredoxin 6: identification of the catalytic triad and its role in phospholipid substrate binding1

Peroxiredoxin 6 (Prdx6) is a bifunctional protein with glutathione peroxidase and phospholipase A2 (PLA2) activities, and it alone among mammalian peroxiredoxins can hydrolyze phospholipids. After identifying a potential catalytic triad (S32, H26, D140) from the crystal structure, site-specific muta...

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Библиографические подробности

Главные авторы:	Yefim Manevich, Konda S. Reddy, Tea Shuvaeva, Sheldon I. Feinstein, Aron B. Fisher
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Elsevier 2007-10-01
Серии:	Journal of Lipid Research
Предметы:	liposomes circular dichroism fluorescence resonance energy transfer site-directed mutagenesis lipid binding peroxidase
Online-ссылка:	http://www.sciencedirect.com/science/article/pii/S0022227520424745
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