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Exploring the heterodimer MDM2/MDM4 interaction region uncovers high-affinity peptides for therapeutic p53-reactivation

IntroductionIn the era of targeted therapies, molecules for the reactivation of the oncosuppressor p53 in human cancer have not yet reached FDA or EMA approval. Recently, the interaction region of the MDM2/MDM4 heterodimer, the most efficient inhibitor of p53 levels and function, has been successful...

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Kaydedildi:
Asıl Yazarlar: Marika Attili, Sonia Valentini, Maria Pesavento, Marco Ballarotto, Viviana Scognamiglio, Alfredo Pontecorvi, Antonio Macchiarulo, Fulvio Saccoccia, Fabiola Moretti
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Frontiers Media S.A. 2025-05-01
Seri Bilgileri:Frontiers in Chemical Biology
Konular:
target p53
peptide
MDM2
MDM4 (MDMX)
umbrella sampling
Online Erişim:https://www.frontiersin.org/articles/10.3389/fchbi.2025.1576640/full
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