A GMCSF-Neuroantigen Tolerogenic Vaccine Elicits Systemic Lymphocytosis of CD4+ CD25high FOXP3+ Regulatory T Cells in Myelin-Specific TCR Transgenic Mice Contingent Upon Low-Efficiency T Cell Antigen Receptor Recognition

Previous studies showed that single-chain fusion proteins comprised of GM-CSF and major encephalitogenic peptides of myelin, when injected subcutaneously in saline, were potent tolerogenic vaccines that suppressed experimental autoimmune encephalomyelitis (EAE) in rats and mice. These tolerogenic va...

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Detaylı Bibliyografya

Asıl Yazarlar:	Cody D. Moorman, Alan D. Curtis, Alexander G. Bastian, Sarah E. Elliott, Mark D. Mannie
Materyal Türü:	Artigo
Dil:	Inglês
Baskı/Yayın Bilgisi:	Frontiers Media S.A. 2019-01-01
Seri Bilgileri:	Frontiers in Immunology
Konular:	FOXP3 Tregs GM-CSF neuroantigen EAE tolerance
Online Erişim:	https://www.frontiersin.org/article/10.3389/fimmu.2018.03119/full
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