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Clinical Significance of ROS1 Rearrangements in Non-small Cell Lung Cancer

Chromosomal rearrangements involving the ROS1 receptor tyrosine kinase gene have recently been described in multiple malignancies, including non-small cell lung cancer (NSCLC). ROS1 rearrangement defines a new molecular subset of NSCLC with the prevalence of ROS1 rearrangements around 1%-2%. ROS1-po...

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Principais autores: Luting XU, Ruijing ZHAO, Zengjun DONG, Tienian ZHU
Formato: Artigo
Idioma:Chinês
Publicado em: Chinese Anti-Cancer Association; Chinese Antituberculosis Association 2013-12-01
coleção:Chinese Journal of Lung Cancer
Assuntos:
ROS1 receptor tyrosine kinase
Anaplastic lymphoma kinase
Lung neoplasms
Crizotinib
Personalized medicine
Acesso em linha:http://dx.doi.org/10.3779/j.issn.1009-3419.2013.12.09
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