Acetyl-DL-leucine in two individuals with REM sleep behavior disorder improves symptoms, reverses loss of striatal dopamine-transporter binding and stabilizes pathological metabolic brain pattern—case reports

Abstract Isolated REM Sleep Behavior Disorder (iRBD) is considered a prodrome of Parkinson’s disease (PD). We investigate whether the potentially disease-modifying compound acetyl-DL-leucine (ADLL; 5 g/d) has an effect on prodromal PD progression in 2 iRBD-patients. Outcome parameters are RBD-severi...

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Hauptverfasser:	Wolfgang H. Oertel, Annette Janzen, Martin T. Henrich, Fanni F. Geibl, Elisabeth Sittig, Sanne K. Meles, Giulia Carli, Klaus Leenders, Jan Booij, D. James Surmeier, Lars Timmermann, Michael Strupp
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Portfolio 2024-09-01
Schriftenreihe:	Nature Communications
Online-Zugang:	https://doi.org/10.1038/s41467-024-51502-7
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