A saturation-mutagenesis analysis of the interplay between stability and activation in Ras

Cancer mutations in Ras occur predominantly at three hotspots: Gly 12, Gly 13, and Gln 61. Previously, we reported that deep mutagenesis of H-Ras using a bacterial assay identified many other activating mutations (Bandaru et al., 2017). We now show that the results of saturation mutagenesis of H-Ras...

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Detalhes bibliográficos

Principais autores:	Frank Hidalgo, Laura M Nocka, Neel H Shah, Kent Gorday, Naomi R Latorraca, Pradeep Bandaru, Sage Templeton, David Lee, Deepti Karandur, Jeffrey G Pelton, Susan Marqusee, David Wemmer, John Kuriyan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	eLife Sciences Publications Ltd 2022-03-01
coleção:	eLife
Assuntos:	saturation-mutagenesis k-ras h-ras high throughput screening cancer mutants signaling activation
Acesso em linha:	https://elifesciences.org/articles/76595
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