Pharmacokinetic interaction between single and multiple doses of darunavir, in combination with cobicistat or ritonavir, and single-dose dabigatran etexilate in healthy adults

Abstract Objective Darunavir (DRV) is a P-glycoprotein (P-gp) inhibitor. Dabigatran etexilate, prodrug of the anticoagulant dabigatran, is a P-gp probe substrate. This study evaluated the effect of single and multiple doses of DRV, coadministered with cobicistat (COBI) or ritonavir (rtv), on the pha...

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Autors principals:	Sandy Van Hemelryck, Erika Van Landuyt, Jay Ariyawansa, Martyn Palmer, Martine J. C. Kothe, Caroline Pollefliet
Format:	Artigo
Idioma:	Inglês
Publicat:	SpringerOpen 2024-10-01
Col·lecció:	AAPS Open
Matèries:	Darunavir Ritonavir Cobicistat Dabigatran Drug-drug interaction
Accés en línia:	https://doi.org/10.1186/s41120-024-00097-w
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