Minimal twister sister-like self-cleaving ribozymes in the human genome revealed by deep mutational scanning

Despite their importance in a wide range of living organisms, self-cleaving ribozymes in the human genome are few and poorly studied. Here, we performed deep mutational scanning and covariance analysis of two previously proposed self-cleaving ribozymes (LINE-1 and OR4K15). We found that the regions...

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Bibliografische Detailangaben

Hauptverfasser:	Zhe Zhang, Xu Hong, Peng Xiong, Junfeng Wang, Yaoqi Zhou, Jian Zhan
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	eLife Sciences Publications Ltd 2024-12-01
Schriftenreihe:	eLife
Schlagworte:	self-cleaving ribozyme deep mutational scanning RNA structure covariation catalytic RNA
Online-Zugang:	https://elifesciences.org/articles/90254
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