The mechanosensitive lncRNA Neat1 promotes osteoblast function through paraspeckle-dependent Smurf1 mRNA retention

Abstract Mechanical stimulation plays an important role in bone remodeling. Exercise-induced mechanical loading enhances bone strength, whereas mechanical unloading leads to bone loss. Increasing evidence has demonstrated that long noncoding RNAs (lncRNAs) play key roles in diverse biological, physi...

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Detalhes bibliográficos

Principais autores:	Caizhi Liu, Xingcheng Gao, Yuheng Li, Weijia Sun, Youjia Xu, Yingjun Tan, Ruikai Du, Guohui Zhong, Dingsheng Zhao, Zizhong Liu, Xiaoyan Jin, Yinlong Zhao, Yinbo Wang, Xinxin Yuan, Junjie Pan, Guodong Yuan, Youyou Li, Wenjuan Xing, Guanghan Kan, Yanqing Wang, Qi Li, Xuan Han, Jianwei Li, Shukuan Ling, Yingxian Li
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 2022-02-01
coleção:	Bone Research
Acesso em linha:	https://doi.org/10.1038/s41413-022-00191-3
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