Complete loss of TP53 and RB1 is associated with complex genome and low immune infiltrate in pleomorphic rhabdomyosarcoma

Summary: Rhabdomyosarcoma accounts for roughly 1% of adult sarcomas, with pleomorphic rhabdomyosarcoma (PRMS) as the most common subtype. Survival outcomes remain poor for patients with PRMS, and little is known about the molecular drivers of this disease. To better characterize PRMS, we performed a...

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Principais autores:	Hannah C. Beird, Chia-Chin Wu, Michael Nakazawa, Davis Ingram, Joseph R. Daniele, Rossana Lazcano, Latasha Little, Christopher Davies, Najat C. Daw, Khalida Wani, Wei-Lien Wang, Xingzhi Song, Curtis Gumbs, Jianhua Zhang, Brian Rubin, Anthony Conley, Adrienne M. Flanagan, Alexander J. Lazar, P. Andrew Futreal
Format:	Artigo
Jezik:	Inglês
Izdano:	Elsevier 2023-10-01
Serija:	HGG Advances
Teme:	Rhabdomyosarcoma Sarcoma TP53 Complex karyotype Pleomorphic rhabdomyosarcoma
Online dostop:	http://www.sciencedirect.com/science/article/pii/S2666247723000568
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