Intensification of Double Kinetic Resolution of Chiral Amines and Alcohols via Chemoselective Formation of a Carbonate–Enzyme Intermediate

Chiral amines and alcohols are synthons of numerous pharmaceutically-relevant compounds. The previously developed enzymatic kinetic resolution approaches utilize a chiral racemic molecule and achiral acyl donor (or acyl acceptor). Thus, only one enantiodivergent step of the catalytic cycle is engage...

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Principais autores:	Jan Samsonowicz-Górski, Anna Brodzka, Ryszard Ostaszewski, Dominik Koszelewski
格式:	Artigo
语言:	Inglês
出版:	MDPI AG 2022-07-01
丛编:	Molecules
主题:	enantioselectivity lipase substrate engineering chemoselectivity biocatalysis carbonates
在线阅读:	https://www.mdpi.com/1420-3049/27/14/4346
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