TSSC3 promotes autophagy via inactivating the Src-mediated PI3K/Akt/mTOR pathway to suppress tumorigenesis and metastasis in osteosarcoma, and predicts a favorable prognosis

Abstract Background Over the last two or three decades, the pace of development of treatments for osteosarcoma tends has been slow. Novel effective therapies for osteosarcoma are still lacking. Previously, we reported that tumor-suppressing STF cDNA 3 (TSSC3) functions as an imprinted tumor suppress...

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Ngā taipitopito rārangi puna kōrero

Ngā kaituhi matua:	Guo-sheng Zhao, Zi-ran Gao, Qiao Zhang, Xue-feng Tang, Yang-fan Lv, Zhao-si Zhang, Yuan Zhang, Qiu-lin Tan, Dong-bin Peng, Dian-ming Jiang, Qiao-Nan Guo
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	BMC 2018-08-01
Rangatū:	Journal of Experimental & Clinical Cancer Research
Ngā marau:	TSSC3 Autophagy Osteosarcoma ATG5 Src PI3K/Akt/mTOR
Urunga tuihono:	http://link.springer.com/article/10.1186/s13046-018-0856-6
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!