Inhibition of Enzymatic Acetylation-Mediated Resistance to Plazomicin by Silver Ions

Plazomicin is a recent U.S. Food and Drug Administration (FDA)-approved semisynthetic aminoglycoside. Its structure consists of a sisomicin scaffold modified by adding a 2(S)-hydroxy aminobutyryl group at the N1 position and a hydroxyethyl substituent at the 6′ position. These substitutions produced...

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Principais autores:	David Ngo, Angel J. Magaña, Tung Tran, Jan Sklenicka, Kimberly Phan, Brian Eykholt, Verónica Jimenez, María S. Ramirez, Marcelo E. Tolmasky
Formato:	Artigo
Idioma:	Inglês
Publicado:	MDPI AG 2023-02-01
Series:	Pharmaceuticals
Assuntos:	AAC(2′)-Ia aminoglycoside 2′-<i>N</i>-acetyltransferase type Ia aminoglycoside multidrug resistance metal ions plazomicin
Acceso en liña:	https://www.mdpi.com/1424-8247/16/2/236
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