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Reduced CD5 on CD8+ T Cells in Tumors but Not Lymphoid Organs Is Associated With Increased Activation and Effector Function

CD5, a member of the scavenger receptor cysteine-rich superfamily, is a marker for T cells and a subset of B cells (B1a). CD5 associates with T-cell and B-cell receptors and increased CD5 is an indication of B cell activation. In tumor-infiltrating lymphocytes (TILs) isolated from lung cancer patien...

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Библиографические подробности
Главные авторы: Faizah Alotaibi, Mark Vincent, Wei-Ping Min, James Koropatnick
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2021-01-01
Серии:Frontiers in Immunology
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Online-ссылка:https://www.frontiersin.org/articles/10.3389/fimmu.2020.584937/full
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