Delivery and Metabolic Fate of Doxorubicin and Betulin Nanoformulations In Vivo: A Metabolomics Approach

<b>Background</b>: Betulins (betulin, betulinic acid and lupeol) demonstrated antitumor and chemopreventive activity but showed low bioavailability due to their self-aggregation in hydrophilic environments. To overcome these disadvantages, their incorporation into lipid nanoformulations (PEGylated l...

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Principais autores:	Mihai Adrian Socaciu, Remus Moldovan, Carmen Socaciu, Flaviu Alexandru Tăbăran, Simona Clichici
格式:	Artigo
语言:	Inglês
出版:	MDPI AG 2025-11-01
丛编:	Metabolites
主题:	pentacyclic triterpenoids PEGylated liposomes Lipid Nanostructured Carriers diffraction light scattering ultra high-performance liquid chromatography Mass Spectrometry
在线阅读:	https://www.mdpi.com/2218-1989/15/11/723
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