Efficient and Robust NK-Cell Transduction With Baboon Envelope Pseudotyped Lentivector

NK-cell resistance to transduction is a major technical hurdle for developing NK-cell immunotherapy. By using Baboon envelope pseudotyped lentiviral vectors (BaEV-LVs) encoding eGFP, we obtained a transduction rate of 23.0 ± 6.6% (mean ± SD) in freshly-isolated human NK-cells (FI-NK) and 83.4 ± 10.1...

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Autors principals:	Aurelien B. L. Colamartino, William Lemieux, Panojot Bifsha, Simon Nicoletti, Nitin Chakravarti, Joaquín Sanz, Hugo Roméro, Silvia Selleri, Kathie Béland, Mélanie Guiot, Camille Tremblay-Laganière, Renée Dicaire, Luis Barreiro, Dean A. Lee, Els Verhoeyen, Elie Haddad
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2019-12-01
Col·lecció:	Frontiers in Immunology
Matèries:	NK-cell transduction baboon retrovirus envelope pseudotyped lentivectors chimeric antigen receptor NK amplification and expansion system (NKAES) cytotoxicity
Accés en línia:	https://www.frontiersin.org/article/10.3389/fimmu.2019.02873/full
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