Emodin promotes GSK-3β-mediated PD-L1 proteasomal degradation and enhances anti-tumor immunity in hepatocellular carcinoma

Abstract Background Programmed death-ligand 1 (PD-L1), a prominent immune checkpoint, interacts with programmed death protein-1 (PD-1) on cytotoxic T cells within tumors and promotes immune evasion. Emodin, which is known to destabilize PD-L1 in breast cancer, has great potential for enhancing anti-...

Descripción completa

Detalles Bibliográficos

Autores principales:	Xuemei Yang, Weiguang Chen, Haitao Sun, Weicong Chen, Wei Xu, Chunyu He, Yang Liu, Ying Kuang, Yanhao Ma, Binglian Zhong, Chaojie Li, Guohuan Li, Qingfeng Du, Songqi He
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2025-08-01
Colección:	Chinese Medicine
Materias:	Hepatocellular carcinoma Emodin PD-L1 GSK-3β
Acceso en línea:	https://doi.org/10.1186/s13020-025-01146-6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!