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Leptin Receptor Deficiency Results in Hyperphagia and Increased Fatty Acid Mobilization during Fasting in Rainbow Trout (<i>Oncorhynchus mykiss</i>)

Leptin is a pleiotropic hormone known for regulating appetite and metabolism. To characterize the role of leptin signaling in rainbow trout, we used CRISPR/Cas9 genome editing to disrupt the leptin receptor (LepR) genes, <i>lepra1</i> and <i>lepra2</i>. We compared wildtype (WT) and mutant fish that...

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Main Authors: Jamie L. Mankiewicz, Matthew J. Picklo, Joseph Idso, Beth M. Cleveland
Format: Artigo
Language:Inglês
Published: MDPI AG 2022-03-01
Series:Biomolecules
Subjects:
leptin receptor
CRISPR
gene editing
growth
rainbow trout
fatty acid
Online Access:https://www.mdpi.com/2218-273X/12/4/516
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