Properties of Stereopure Phosphorothioate Groups in RNA-PROTACs
Proteolysis-targeting chimeras (PROTACs) are an emerging therapeutic modality that enable the degradation of target proteins via the endogenous ubiquitin–proteasome pathway. We are applying this concept to the degradation of RNA-binding proteins (RBPs), which often lack drug-like binding pockets for...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Alemão |
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Swiss Chemical Society
2026-04-01
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| Serie: | CHIMIA |
| Soggetti: | |
| Accesso online: | https://www.chimia.ch/chimia/article/view/10254 |
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