Targeting of mutant p53 and the cellular redox balance by APR-246 as a strategy for efficient cancer therapy

TP53 is the most frequently mutated gene in cancer. The p53 protein activates transcription of genes that promote cell cycle arrest or apoptosis, or regulate cell metabolism and other processes . Missense mutations in TP53 abolish specific DNA binding of p53 and allow evasion of apoptosis and accele...

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Үндсэн зохиолчид:	Vladimir J.N. Bykov, Qiang eZhang, Meiqiongzi eZhang, Sophia eCeder, Lars eAbrahmsen, Klas G Wiman
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Frontiers Media S.A. 2016-02-01
Цуврал:	Frontiers in Oncology
Нөхцлүүд:	Apoptosis Glutathione cancer therapy Clinical Trial mutant p53 thioredoxin reductase
Онлайн хандалт:	http://journal.frontiersin.org/Journal/10.3389/fonc.2016.00021/full
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!