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Inhibitory effects of thromboxane A2 generation by ginsenoside Ro due to attenuation of cytosolic phospholipase A2 phosphorylation and arachidonic acid release

Background: Thromboxane A2 (TXA2) induces platelet aggregation and promotes thrombus formation. Although ginsenoside Ro (G-Ro) from Panax ginseng is known to exhibit a Ca2+-antagonistic antiplatelet effect, whether it inhibits Ca2+-dependent cytosolic phospholipase A2 (cPLA2α) activity to prevent th...

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Autori principali: Jung-Hae Shin, Hyuk-Woo Kwon, Man Hee Rhee, Hwa-Jin Park
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2019-04-01
Serie:Journal of Ginseng Research
Accesso online:http://www.sciencedirect.com/science/article/pii/S1226845317303019
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